I figured out how many of what size blocks I needed and then started throwing blocks up on the design wall. This thing will be about 56" wide by 68" tall. I may do some rearranging of fabrics, but by and large I am ready to start sewing it together. I plan to sew the long columns together first.
One thing I discovered is that this quilt really needs blocks of predominantly one color. Blocks that were made of large prints with other colors didn't work.